Do serum hepcidin-25 levels correlate with oxidative stress in patients with chronic kidney disease not receiving dialysis?

Yukio Maruyama, Keitaro Yokoyama, Hiroyasu Yamamoto, Masaaki Nakayama, Tatsuo Hosoya

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Aims: Iron metabolism is an important factor of anemia in chronic kidney disease (CKD). Hepcidin is a regulator of iron homeostasis and has a major role in the anemia of chronic disease (ACD). Oxidative stress (OS) is also associated with iron metabolism. However, the clinical utility of hepcidin, especially its association with OS, in CKD patients not receiving dialysis is still unclear. Methods: We recruited 117 patients (62 ± 15 years, 85 males, and median estimated glomerular filtration rate (eGFR) 22 ml/ min/1.73 m2) with CKD not receiving dialysis. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of DNA oxidative injury, and serum hepcidin-25 were measured by ELISA and by liquid chromatography tandem mass spectrometry, respectively. Results: Hepcidin-25 was associated positively with ferritin, high-sensitive C-reactive protein (hsCRP) and 8-OHdG, and negatively with eGFR and hemoglobin. Sex, oral iron, hemoglobin, transferrin saturation (TSAT), ferritin, and hsCRP were independently associated with hepcidin-25 in a multiple regression model. In contrast, neither eGFR nor 8-OHdG independently affected hepcidin- 25. Conclusions: The close association between hepcidin and serum ferritin, oral iron and hsCRP indicates that it plays a key role in the pathogenesis of anemia in patients with CKD not receiving dialysis. In contrast, effects of eGFR and OS were not apparent.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalClinical nephrology
Volume78
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

Keywords

  • 8-hydroxy-2'
  • Anemia of chronic disease (ACD)
  • Deoxyguanosine (8-OHdG)
  • Estimated glomerular filtration rate (eGFR)
  • Ferritin
  • High sensitive C-reactive protein (hsCRP)

ASJC Scopus subject areas

  • Nephrology

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