Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?

Yukio Mikami, Kazunori Takeda, Kazuhiko Shibuya, Huang Qiu-Feng, Hiromune Shimamura, Junichiro Yamauchi, Shinichi Egawa, Makoto Sunamura, Hideki Yagi, Yasuo Endo, Seiki Matsuno

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35 Citations (Scopus)

Abstract

Introduction: Macrophages are considered to play an essential role in the events leading to systemic inflammatory response. Some are known to reside in the peritoneal cavity but there are no reports defining the participation of peritoneal macrophages (PMs) in the progression of acute pancreatitis. Aim: To clarify the role of PMs in the progression of acute pancreatitis. Methodology: Acute pancreatitis was induced in rats from which macrophages other than PMs were greatly depleted, and in rats greatly depleted of macrophages including PMs. Macrophages were depleted by the injection of liposome encapsulated dichloromethylene bisphosphonate. After the induction of acute pancreatitis, local pancreatic inflammation, intraperitoneal inflammation and lung injury were compared between the 2 groups. Results: Local pancreatic inflammation did not differ between the 2 groups. However, intraperitoneal inflammation was clearly improved by the depletion of PMs. Serum cytokine level and lung injury were also improved by the depletion of PMs. Conclusion: Peritoneal macrophages extend inflammation from the pancreas to the peritoneal cavity and subsequently induce lung injury in acute pancreatitis. Peritoneal macrophages play an essential role in the systemic inflammatory response and the progression of acute pancreatitis in the rat.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalPancreas
Volume27
Issue number3
DOIs
Publication statusPublished - 2003 Oct 1

Keywords

  • Acute pancreatitis
  • Cytokine
  • Liposome encapsulated dichloromethylene bisphosphonate (ClMBP liposomes)
  • Lung injury
  • Peritoneal macrophage
  • Polymorphonuclear neutrophils

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Mikami, Y., Takeda, K., Shibuya, K., Qiu-Feng, H., Shimamura, H., Yamauchi, J., Egawa, S., Sunamura, M., Yagi, H., Endo, Y., & Matsuno, S. (2003). Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats? Pancreas, 27(3), 253-260. https://doi.org/10.1097/00006676-200310000-00011