DNA vaccines

Masako Toda, M. Sakaguchi

Research output: Contribution to journalReview articlepeer-review


DNA vaccination is a novel immunization technique to induce antigen- specific immune responses. This method is recognized as an attractive approach not only for the vaccines of infectious disease, but for treatment of cancer, autoimmune diseases and allergic diseases. Induction of allergen- specific Th 1 cells by inoculation with plasmid DNA encoding gene of the sensitizing allergens suppresses the activity of Th 2 cells, which would be promising for interfering with the allergic reactions. It has become apparent that immune responses induced by DNA vaccination can be manipulated by altering the condition such as inoculating method or route, or coadministering adjuvant or plasmid DNA encoding gene of costimulatory molecules. In this review, we discuss the potential of DNA vaccination for the treatment of allergic diseases, including recent knowledge.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalIRYO - Japanese Journal of National Medical Services
Issue number2
Publication statusPublished - 2000 Jan 1
Externally publishedYes


  • Allergic diseases
  • DNA vaccine
  • Immunotherapy

ASJC Scopus subject areas

  • Medicine(all)


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