DNA-templated click chemistry for creation of novel DNA binding molecules

Shuhei Imoto, Tomoya Hirohama, Fumi Nagatsugi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have developed a new methodology for producing new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by the addition of dsDNA. Furthermore, the resulting peptide-acridine conjugate showed a slightly stronger binding to dsDNA. These results indicate that the DNA-templated click chemistry is applicable for screening new binding molecules.

Original languageEnglish
Pages (from-to)5660-5663
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - 2008 Oct 15

Keywords

  • Acridine
  • Combinatorial chemistry
  • DNA binding peptide
  • DNA-templated click chemistry

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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