Administration of diabetogenic doses of alloxan or streptozotocin to rats caused extensive DNA strand breaks in pancreatic islets. DNA of pancreatic exocrine cells was not affected by either alloxan or streptozotocin. hepatocyte DNA was fragmented by streptozotocin but not by alloxan. Intracellular NAD level was decreased in tissues whose DNA was fragmented. The results may raise a novel aspect concerning the mechanisms of action of the diabetogenic agents as well as concerning the organotropisms of the agents.
|Number of pages||7|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - 1981 Dec 15|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology