DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin

Hiroshi Yamamoto, Yasuko Uchigata, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Administration of diabetogenic doses of alloxan or streptozotocin to rats caused extensive DNA strand breaks in pancreatic islets. DNA of pancreatic exocrine cells was not affected by either alloxan or streptozotocin. hepatocyte DNA was fragmented by streptozotocin but not by alloxan. Intracellular NAD level was decreased in tissues whose DNA was fragmented. The results may raise a novel aspect concerning the mechanisms of action of the diabetogenic agents as well as concerning the organotropisms of the agents.

Original languageEnglish
Pages (from-to)1014-1020
Number of pages7
JournalBiochemical and biophysical research communications
Volume103
Issue number3
DOIs
Publication statusPublished - 1981 Dec 15
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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