DNA single-strand breaks are increased in muscle diseases with rimmed vacuoles

Maki Tateyama, Muneshige Tobita, Atsushi Takeda, Keiji Chida, Yoshiaki Onodera, Akio Kikuchi, Naoko Aoyagi, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Some pathological similarities between Alzheimer's disease and muscle diseases with rimmed vacuoles (RV) have been pointed out. For example, several pathological hallmark proteins have been reported to be immunopositive in the lesions of both diseases. Since apoptotic processes or primary DNA damage are suggested to play a role in the pathomechanism of Alzheimer's disease, we examined DNA double-strand breaks (DSB) and single-strand breaks (SSB) in the muscle biopsy specimens of several diseases, including muscle diseases with RV. Although no DSB-positive myonuclei were detected in any muscles examined, the number of SSB-positive myonuclei markedly increased in the muscles from cases with polymyositis and muscle diseases with RV. In polymyositis, SSB-positive myonuclei were observed in regenerating fibers and muscle fibers in the vicinity of inflammatory infiltrates, suggesting that the increase of SSB is due to muscle fiber regeneration following necrosis and inflammation. In muscle diseases with RV, however, SSB-positive myonuclei were observed in small angulated fibers and in morphologically normal fibers, regardless of necrosis, regeneration or inflammation. These findings suggest that muscle diseases with RV may share a common pathological process involving DNA damage.

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalActa neuropathologica
Issue number4
Publication statusPublished - 2000 Oct
Externally publishedYes


  • DNA double-strand breaks
  • DNA single-strand breaks
  • In situ nick translation
  • Rimmed vacuole

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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