DNA Origami Nanoplate-Based Emulsion with Nanopore Function

Daisuke Ishikawa; Yuki Suzuki; Chikako Kurokawa; Masayuki Ohara; Misato Tsuchiya; Masamune Morita; Miho Yanagisawa; Masayuki Endo; Ryuji Kawano; Masahiro Takinoue

doi:10.1002/anie.201908392

DNA Origami Nanoplate-Based Emulsion with Nanopore Function

Daisuke Ishikawa, Yuki Suzuki, Chikako Kurokawa, Masayuki Ohara, Misato Tsuchiya, Masamune Morita, Miho Yanagisawa, Masayuki Endo, Ryuji Kawano, Masahiro Takinoue

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Bio-inspired functional microcapsules have attracted increasing attention in many fields from physical/chemical science to artificial-cell engineering. Although particle-stabilised microcapsules are advantageous for their stability and functionalisation potential, versatile methods for their functionalisation are desired to expand their possibilities. This study reports a water-in-oil microdroplet stabilised with amphiphilic DNA origami nanoplates. By utilising DNA nanotechnology, DNA nanoplates were designed as a nanopore device for ion transportation and to stabilise the oil–water interface. Microscopic examination revealed the microcapsule formed by the accumulation of amphiphilic DNA nanoplates at the oil–water interface. Ion current measurements revealed the nanoplate pores functioned as channel to transport ions. These findings provide a general strategy for the programmable design of microcapsules to engineer artificial cells and molecular robots.

Original language	English
Pages (from-to)	15299-15303
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	58
Issue number	43
DOIs	https://doi.org/10.1002/anie.201908392
Publication status	Published - 2019 Oct 21
Externally published	Yes

Keywords

DNA nanotechnology
Pickering emulsion
bio-inspired system
nanopore
self-assembly

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201908392

Cite this

@article{977a3beadbdf4de0a6f841c4600a0917,

title = "DNA Origami Nanoplate-Based Emulsion with Nanopore Function",

abstract = "Bio-inspired functional microcapsules have attracted increasing attention in many fields from physical/chemical science to artificial-cell engineering. Although particle-stabilised microcapsules are advantageous for their stability and functionalisation potential, versatile methods for their functionalisation are desired to expand their possibilities. This study reports a water-in-oil microdroplet stabilised with amphiphilic DNA origami nanoplates. By utilising DNA nanotechnology, DNA nanoplates were designed as a nanopore device for ion transportation and to stabilise the oil–water interface. Microscopic examination revealed the microcapsule formed by the accumulation of amphiphilic DNA nanoplates at the oil–water interface. Ion current measurements revealed the nanoplate pores functioned as channel to transport ions. These findings provide a general strategy for the programmable design of microcapsules to engineer artificial cells and molecular robots.",

keywords = "DNA nanotechnology, Pickering emulsion, bio-inspired system, nanopore, self-assembly",

author = "Daisuke Ishikawa and Yuki Suzuki and Chikako Kurokawa and Masayuki Ohara and Misato Tsuchiya and Masamune Morita and Miho Yanagisawa and Masayuki Endo and Ryuji Kawano and Masahiro Takinoue",

note = "Funding Information: We thank Dr. Yusuke Sato (Tokyo Tech) for helpful discussions. This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas ?Molecular Robotics? to M. Takinoue (M.Tk.), M.E. (No. 24104002) and R.K. (No. 15H00803) from MEXT; JSPS KAKENHI to M.Tk. (No. 26280097, 17H01813, 18K19834), R.K. (No. 17H01813), M.E. (No. 15H03837, 16K14033, 18KK0139), and Y.S. (No. 18K19831); Research Encouragement Grants from The Asahi Glass Foundation to M.Tk. and D.I.; Support for Tokyo Tech Advanced Researchers (STAR) to M.Tk.; and Foundation from Oil & Fat Industry Kaikan to D.I; Research grants from The Naito Foundation to M.Y. Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2019",

month = oct,

day = "21",

doi = "10.1002/anie.201908392",

language = "English",

volume = "58",

pages = "15299--15303",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "43",

}

TY - JOUR

T1 - DNA Origami Nanoplate-Based Emulsion with Nanopore Function

AU - Ishikawa, Daisuke

AU - Suzuki, Yuki

AU - Kurokawa, Chikako

AU - Ohara, Masayuki

AU - Tsuchiya, Misato

AU - Morita, Masamune

AU - Yanagisawa, Miho

AU - Endo, Masayuki

AU - Kawano, Ryuji

AU - Takinoue, Masahiro

N1 - Funding Information: We thank Dr. Yusuke Sato (Tokyo Tech) for helpful discussions. This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas ?Molecular Robotics? to M. Takinoue (M.Tk.), M.E. (No. 24104002) and R.K. (No. 15H00803) from MEXT; JSPS KAKENHI to M.Tk. (No. 26280097, 17H01813, 18K19834), R.K. (No. 17H01813), M.E. (No. 15H03837, 16K14033, 18KK0139), and Y.S. (No. 18K19831); Research Encouragement Grants from The Asahi Glass Foundation to M.Tk. and D.I.; Support for Tokyo Tech Advanced Researchers (STAR) to M.Tk.; and Foundation from Oil & Fat Industry Kaikan to D.I; Research grants from The Naito Foundation to M.Y. Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/10/21

Y1 - 2019/10/21

N2 - Bio-inspired functional microcapsules have attracted increasing attention in many fields from physical/chemical science to artificial-cell engineering. Although particle-stabilised microcapsules are advantageous for their stability and functionalisation potential, versatile methods for their functionalisation are desired to expand their possibilities. This study reports a water-in-oil microdroplet stabilised with amphiphilic DNA origami nanoplates. By utilising DNA nanotechnology, DNA nanoplates were designed as a nanopore device for ion transportation and to stabilise the oil–water interface. Microscopic examination revealed the microcapsule formed by the accumulation of amphiphilic DNA nanoplates at the oil–water interface. Ion current measurements revealed the nanoplate pores functioned as channel to transport ions. These findings provide a general strategy for the programmable design of microcapsules to engineer artificial cells and molecular robots.

AB - Bio-inspired functional microcapsules have attracted increasing attention in many fields from physical/chemical science to artificial-cell engineering. Although particle-stabilised microcapsules are advantageous for their stability and functionalisation potential, versatile methods for their functionalisation are desired to expand their possibilities. This study reports a water-in-oil microdroplet stabilised with amphiphilic DNA origami nanoplates. By utilising DNA nanotechnology, DNA nanoplates were designed as a nanopore device for ion transportation and to stabilise the oil–water interface. Microscopic examination revealed the microcapsule formed by the accumulation of amphiphilic DNA nanoplates at the oil–water interface. Ion current measurements revealed the nanoplate pores functioned as channel to transport ions. These findings provide a general strategy for the programmable design of microcapsules to engineer artificial cells and molecular robots.

KW - DNA nanotechnology

KW - Pickering emulsion

KW - bio-inspired system

KW - nanopore

KW - self-assembly

UR - http://www.scopus.com/inward/record.url?scp=85073184893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073184893&partnerID=8YFLogxK

U2 - 10.1002/anie.201908392

DO - 10.1002/anie.201908392

M3 - Article

C2 - 31411794

AN - SCOPUS:85073184893

VL - 58

SP - 15299

EP - 15303

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 43

ER -

DNA Origami Nanoplate-Based Emulsion with Nanopore Function

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this