DNA hydrogels as a scaffold for organs-on-chips: Study of buoyancy and sedimentation of microbeads in DNA gels

Emilie Belot, Yannick Tauran, Yusuke Sato, Masahiro Takinoue, Arnaud Brioude, Teruo Fujii, Anthony J. Genot

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydrogels lie at the heart of the organ-on-chip approach. Their physicochemistry and rheology largely determine the outcome of tissue engineering. DNA hydrogels are emerging as a promising medium due to their biocompatibility and physicochemical programmability. However their use as a scaffold for tissue engineering has been little studied. Here we study the buoyancy and sedimentation of microbeads suspended in DNA gels and culture medium. We identify the parameters (binding strengths and concentration of DNA strands) that should enable stable suspension and culture of cells.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1057-1058
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • DNA Nanotechnology
  • Hydrogels
  • Microbeads
  • Sedimentation

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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