DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Takashi Takahashi, Hiroshi Tanaka, Akihisa Matsuda, Takayuki Doi, Haruo Yamada, Takuyuki Matsumoto, Daisuke Sasaki, Yukio Sugiura

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.

Original languageEnglish
Pages (from-to)3303-3306
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
Publication statusPublished - 1998 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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