Diverse effects of calcium antagonists on glomerular hemodynamics

S. Arima, S. Ito, K. Omata, K. Tsunoda, H. Yaoita, K. Abe

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Abstract

This study examined the direct effects of calcium antagonists on glomerular hemodynamics. Rabbit afferent (Af-) or efferent arterioles (Ef-Arts) were microperfused in vitro at constant pressure. Ef-Arts were perfused from the distal end of Af-Art through the glomerulus. Increasing doses (10-10 to 10-7 M) of nifedipine (Nif), nicardipine (Nic) or manidipine (Man) were added into the lumen of Af- or Ef-Arts preconstricted (by about 40%) with norepinephrine. Although Nif and Nic dilated Af-Arts in a dose-dependent manner, they did not cause any dilation in Ef-Arts. In contrast, Man dilated both Af- and Ef-Arts in a dose dependent manner; Man at 10-7 M dilated Af- and Ef-Arts by 71 ± 12% (N = 7) and 38 ± 3% (N = 6), respectively. Although Man's dilator effect on Ef-Art was not affected by inhibiting nitric oxide (NO) synthesis (N = 6), it was markedly attenuated by eliminating the influence of glomerulus (14 ± 3% by Man at 10-7 M, N = 5). These results demonstrate that in addition to dilating Af-Art, Man, but not Nif or Nic, dilates Ef-Art through a glomerulus-derived vasodilator(s) other than NO. Such diverse actions should be taken into consideration when calcium antagonists are used in the treatment of patients with cardiovascular and renal diseases.

Original languageEnglish
Pages (from-to)S-132-S-134
JournalKidney International, Supplement
Issue number55
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Nephrology

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    Arima, S., Ito, S., Omata, K., Tsunoda, K., Yaoita, H., & Abe, K. (1996). Diverse effects of calcium antagonists on glomerular hemodynamics. Kidney International, Supplement, (55), S-132-S-134.