Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

Shinya Hanashima, Shino Manabe, Yukishige Ito

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl.

Original languageEnglish
Pages (from-to)4218-4224
Number of pages7
JournalAngewandte Chemie - International Edition
Volume44
Issue number27
DOIs
Publication statusPublished - 2005 Jul 4
Externally publishedYes

Keywords

  • Carbohydrates
  • Glycoproteins
  • Glycosylation
  • Oligosaccharides
  • Sialic acids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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