Distribution of various calcium channel α1 subunits in murine DRG neurons and antinociceptive effect of ω-conotoxin SVIB in mice

Manabu Murakami, Takashi Suzuki, Osamu Nakagawasai, Hiroshi Murakami, Shinobu Murakami, Akihisa Esashi, Ryoo Taniguchi, Teruyuki Yanagisawa, Koichi Tan-No, Ichiro Miyoshi, Hironobu Sasano, Takeshi Tadano

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Immunohistological study revealed the differential localization of subtypes of voltage-dependent calcium channels in the dorsal root ganglion neurons. Intrathecal injection of ω-conotoxin SVIB, an analogue of ω-conotoxin GVIA, which acts on N-type voltage-dependent calcium channels, significantly shortened the licking time in the late phase of a formalin test.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalBrain research
Volume903
Issue number1-2
DOIs
Publication statusPublished - 2001 Jun 8

Keywords

  • Calcium channel
  • Nociception
  • ω-Conotoxin SVIB

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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