Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry

Tomokazu Fukuda, Toshiyuki Kobayashi, Hideaki Yasui, Masahiro Tsutsumi, Yoichi Konishi, Okio Hino

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Alterations in the rat tuberous sclerosis gene (Tsc2) are responsible for the hereditary renal carcinomas (RCs) of Eker rat. We examined protein distribution in various normal rat tissues and the Eker RCs by immunohistochemistry. Tsc2 protein is expressed in the mammary ducts, salivary glands, gastric glands, parathyroid, small and large intestine, ovary and uterus. Specific expression of Tsc2 protein is found in the B cells of pancreatic islets and in the smooth muscle of lung veins. Interestingly, in the RCs of Eker rat, TsC2 protein was detectable with some variation in reactivity.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalVirchows Archiv
Volume434
Issue number4
DOIs
Publication statusPublished - 1999 May 10

Keywords

  • Eker rat
  • Renal cell carcinoma
  • Tsc2 protein
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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