Distribution of the HLA class I allele in chronic hepatitis C and its association with serum ALT level in chronic hepatitis C

Yasuteru Kondo, Koju Kobayashi, Tomoo Kobayashi, Masaaki Shiina, Yoshiyuki Ueno, Takaomi Satoh, Tooru Shimosegawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An essential process for resolution of viral infections is the efficient recognition and elimination of intracellular virus. Recognition of viral antigens in the form of short peptides associated with HLA class I molecule is a major task of CD8+ cytotoxic T lymphocytes. In this study, we have evaluated the frequency of the HLA class I alleles in patients with chronic hepatitis C. HLA-B51, -B52, -B55, -B56, -B61, B70, -Cw1, -Cw3, and -Cw4 are less frequent in patients with chronic hepatitis C than in Japanese individuals. The frequency of HLA-A2 is slightly lower in the patients but tends to be higher in patients with normal alanine aminotransferase (ALT) level than in those with elevated ALT level (p=0.07). Other HLA alleles are not significantly different between two groups. Cqmparison of HLA homozygosity at HLA-A and -B or -C or at two or three loci did not show a significant association with levels of serum ALT or with the clinical outcome of interferon therapy in patients with hepatitis C. These results suggest a possibility that the alterations of host response, which depends on genetic background, influence disease activities of HCV infection.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalTohoku Journal of Experimental Medicine
Volume201
Issue number2
DOIs
Publication statusPublished - 2003 Oct

Keywords

  • CTL
  • Cellular immune response
  • HLA class I allele
  • HLA-A2
  • Japanese individuals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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