Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients

R. Doi-Yi, T. Kitamoto, K. Ogomori, P. Mehraein, J. Tateishi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.

Original languageEnglish
Pages (from-to)481-483
Number of pages3
JournalActa neuropathologica
Volume87
Issue number5
DOIs
Publication statusPublished - 1994 May 1
Externally publishedYes

Keywords

  • Creutzfeld-Jakob disease (CJD)
  • Genotypes
  • Gerstmann-Sträussler-Scheinker syndrome (GSS)
  • Phenotypes
  • Prion protein (PrP)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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