Distribution of carbon-11 labeled methamphetamine and the effect of its chronic administration in mice

Michinao Mizugaki, Takanori Hishinuma, Hitoshi Nakamura, Masamichi Yamashita, Kohichi Shimomura, Kunihiko Itoh, Akihiko Hirose, Yoshihisa Tomioka, Hisashi Aso, Kiyoto Edo, Toshihiro Takahashi, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

[11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was investigated in the mice brain at various intervals after an intravenous (i.v.) injection. Radioactivity was higher in the hypothalamus, cortex, striatum and hippocampus. Furthermore, in chronically administered mice, the uptake of [11C]methamphetamine was higher in the striatum than those in other regions. The regional differences in the distribution of methamphetamine in the mice brain may enable the imaging of its distribution by PET using [11C]methamphetamine.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalNuclear Medicine and Biology
Volume20
Issue number4
DOIs
Publication statusPublished - 1993 May

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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