Distribution of calcitonin gene- related peptide and substance P-lmmunoreactive nerve fibers and their correlation in the periodontal ligament of the mouse incisor

J. Kato, K. Tanne, H. Ichikawa, S. Matsuo, S. Wakisaka, M. Akai, K. Kurisu, M. Sakuda

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The distribution of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive (IR) nerve fibers and their correlation in the periodontal ligament of mouse incisors were examined by indirect immunofluorescence. Both CGRP-IR and SP-IR thin nerve fibers were abundant in the apical and middle third of the periodontal ligament. In the lingual portion of the incisal periodontal ligament, these nerve fibers were localized in the alveolar half of the periodontal ligament and were observed as free nerve endings. No CGRP-IR and SP-IR specialized nerve endings, such as Ruffini-like corpuscles, were observed. In the labial periodontal ligament. CGRP-IR and SP-IR nerve fibers ran along the incisal axis. The distribution of CGRP-IR nerve fibers was very similar to that of SP-IR nerve fibers.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalCells Tissues Organs
Volume145
Issue number2
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Keywords

  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Incisor
  • Mouse
  • Periodontal ligament
  • Substance P

ASJC Scopus subject areas

  • Anatomy
  • Histology

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