Distinctive flow pattern of wall shear stress and oscillatory shear index: Similarity and dissimilarity in ruptured and unruptured cerebral aneurysm blebs

Tomohiro Kawaguchi, Shinjitsu Nishimura, Masayuki Kanamori, Hiroki Takazawa, Shunsuke Omodaka, Kenya Sato, Noriko Maeda, Yoko Yokoyama, Hiroshi Midorikawa, Tatsuya Sasaki, Michiharu Nishijima

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Object: The difference in the hemodynamics of wall shear stress (WSS) and oscillatory shear index (OSI) between ruptured and unruptured aneurysms is not well understood. The authors investigated the hemodynamic similarities and dissimilarities in ruptured and thin-walled unruptured aneurysm blebs. Methods: Magnetic resonance imaging-based fluid dynamics analysis was used to calculate WSS and OSI, and hemodynamic and intraoperative findings were compared. The authors also compared ruptured and unruptured thinwalled blebs for the magnitude of WSS and OSI. Results: Intraoperatively, 13 ruptured and 139 thin-walled unruptured aneurysm blebs were identified. Twelve of the ruptured (92.3%) and 124 of the unruptured blebs (89.2%) manifested low WSS and high OSI. The degree of WSS was significantly lower in ruptured (0.49 ± 0.12 Pa) than in unruptured (0.64 ± 0.15 Pa; p < 0.01) blebs. Conclusions: Ruptured and unruptured blebs shared a distinctive pattern of low WSS and high OSI. The degree of WSS at the rupture site was significantly lower than in the unruptured thin-walled blebs.

Original languageEnglish
Pages (from-to)774-780
Number of pages7
JournalJournal of neurosurgery
Volume117
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

Keywords

  • Cerebral aneurysm
  • Fluid dynamics analysis
  • Oscillatory shear index
  • Vascular disorders
  • Wall shear stress

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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