TY - JOUR
T1 - Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging
AU - Gerasimenko, Maria
AU - Lopatina, Olga
AU - Shabalova, Anna A.
AU - Cherepanov, Stanislav M.
AU - Salmina, Alla B.
AU - Yokoyama, Shigeru
AU - Goto, Hisanori
AU - Okamoto, Hiroshi
AU - Yamamoto, Yasuhiko
AU - Ishihara, Katsuhiko
AU - Higashida, Haruhiro
N1 - Funding Information:
We acknowledge financial supports from the Kanazawa University SAKIGAKE project 2018 and Takeda Science Foundation, Japan. We thank the Grants-in-Aid for Scientific Research (24590375, 25461335 and 18K06889) and Program for Fostering Globally Talented Researchers from the Japan Society for Promotion of Sciences.
Publisher Copyright:
© 2020 Gerasimenko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020/12
Y1 - 2020/12
N2 - The ability of CD38 and CD157 to utilize nicotinamide adenine dinucleotide (NAD) has received much attention because the aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare the effects of age-associated changes on the general health and brain function impairment of Cd157 and Cd38 knockout (CD157 KO and CD38 KO) mice. The body weight and behaviors were measured in 8-week-old (young adult) or 12-month-old (middle-aged) male mice of both KO strains. The locomotor activity, anxiety-like behavior, and social behavior of the mice were measured in the open field and three-chamber tests. The middleaged CD157 KO male mice gained more body weight than young adult KO mice, while little or no body weight gain was observed in the middle-aged CD38 KO mice. Middle-aged CD157 KO mice displayed increased anxiety-like behavior and decreased sociability and interaction compared with young adult KO mice. Middle-aged CD38 KO mice showed less anxiety and hyperactivity than CD157 KO mice, similar to young adult CD38 KO mice. The results reveal marked age-dependent changes in male CD157 KO mice but not in male CD38 KO mice. We discuss the distinct differences in aging effects from the perspective of inhibition of NAD metabolism in CD157 and CD38 KO mice, which may contribute to differential behavioral changes during aging.
AB - The ability of CD38 and CD157 to utilize nicotinamide adenine dinucleotide (NAD) has received much attention because the aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare the effects of age-associated changes on the general health and brain function impairment of Cd157 and Cd38 knockout (CD157 KO and CD38 KO) mice. The body weight and behaviors were measured in 8-week-old (young adult) or 12-month-old (middle-aged) male mice of both KO strains. The locomotor activity, anxiety-like behavior, and social behavior of the mice were measured in the open field and three-chamber tests. The middleaged CD157 KO male mice gained more body weight than young adult KO mice, while little or no body weight gain was observed in the middle-aged CD38 KO mice. Middle-aged CD157 KO mice displayed increased anxiety-like behavior and decreased sociability and interaction compared with young adult KO mice. Middle-aged CD38 KO mice showed less anxiety and hyperactivity than CD157 KO mice, similar to young adult CD38 KO mice. The results reveal marked age-dependent changes in male CD157 KO mice but not in male CD38 KO mice. We discuss the distinct differences in aging effects from the perspective of inhibition of NAD metabolism in CD157 and CD38 KO mice, which may contribute to differential behavioral changes during aging.
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U2 - 10.1371/journal.pone.0244022
DO - 10.1371/journal.pone.0244022
M3 - Article
C2 - 33326496
AN - SCOPUS:85098280661
VL - 15
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12 December
M1 - e0244022
ER -