Distinct Cancer-Specific Survival in Metastatic Prostate Cancer Patients Classified by a Panel of Single Nucleotide Polymorphisms of Cancer-Associated Genes

Norihiko Tsuchiya, Shigeyuki Matsui, Shintaro Narita, Tomomi Kamba, Koji Mitsuzuka, Shingo Hatakeyama, Yohei Horikawa, Takamitsu Inoue, Seiichi Saito, Chikara Ohyama, Yoich Arai, Osamu Ogawa, Tomonori Habuchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Individual genetic variations may have a significant influence on the survival of metastatic prostate cancer (PCa) patients. We aimed to identify target genes and their variations involved in the survival of PCa patients using a single nucleotide polymorphism (SNP) panel. A total of 185 PCa patients with bone metastasis at the initial diagnosis were analyzed. Germline DNA in each patient was genotyped using a cancer SNP panel that contained 1,421 SNPs in 408 cancer-related genes. SNPs associated with survival were screened by a log-rank test. Fourteen SNPs in 6 genes, XRCC4, PMS1, GATA3, IL13, CASP8, and IGF1, were identified to have a statistically significant association with cancer-specific survival. The cancer-specific survival times of patients grouped according to the number of risk genotypes of 6 SNPs selected from the 14 SNPs differed significantly (0-1 v. 2-3 v. 4-6 risk genotypes; P = 7.20 × 10-8). The high-risk group was independently associated with survival in a multivariate analysis that included conventional clinicopathological variables (P = 0.0060). We identified 14 candidate SNPs in 6 cancer-related genes, which were associated with poor survival in patients with metastatic PCa. A panel of SNPs may help predict the survival of those patients.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalGenes and Cancer
Volume4
Issue number1-2
DOIs
Publication statusPublished - 2013 Mar 1

Keywords

  • bone metastasis
  • prostate cancer
  • single nucleotide polymorphism
  • survival

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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    Tsuchiya, N., Matsui, S., Narita, S., Kamba, T., Mitsuzuka, K., Hatakeyama, S., Horikawa, Y., Inoue, T., Saito, S., Ohyama, C., Arai, Y., Ogawa, O., & Habuchi, T. (2013). Distinct Cancer-Specific Survival in Metastatic Prostate Cancer Patients Classified by a Panel of Single Nucleotide Polymorphisms of Cancer-Associated Genes. Genes and Cancer, 4(1-2), 54-60. https://doi.org/10.1177/1947601913481354