Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction

Mitsuharu Sato, Hirofumi Suemori, Naoki Hata, Masataka Asagiri, Kouetsu Ogasawara, Kazuki Nakao, Takeo Nakaya, Motoya Katsuki, Shigeru Noguchi, Nobuyuki Tanaka, Tadatsugu Taniguchi

Research output: Contribution to journalArticlepeer-review

1029 Citations (Scopus)

Abstract

Induction of the interferon (IFN)-α/β gene transcription in virus-infected cells is an event central to innate immunity. Mice lacking the transcription factor IRF-3 are more vulnerable to virus infection. In embryonic fibroblasts, virus-induced IFN-α/β gene expression levels are reduced and the spectrum of the IFN-α mRNA subspecies altered. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. In these cells, a normal profile of IFN-α/β mRNA induction can be achieved by coexpressing both IRF-3 and IRF-7. These results demonstrate the essential and distinct roles of the two factors, which together ensure the transcriptional efficiency and diversity of IFN-α/β genes for the antiviral response.

Original languageEnglish
Pages (from-to)539-548
Number of pages10
JournalImmunity
Volume13
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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