Abstract
A markedly effective treatment for cancer resulted frequently in a fatal outcome with disseminated intravascular coagulation (DIC). Recently we developed a new drug delivery system, designated as Flooding-the-castle chemotherapy (FCC). FCC could selectively enhance the drug concentration and its retention time in tumor tissues. This treatment caused marked effects of the anticancer drug on sc transplanted solid tumors, with resulting severe DIC. An attack of DIC depended on the difference of tumor strains. Rats bearing AH272 tumor did not cause DIC even in complete cures following FCC. AH109A tumors, on the other hand, produced fatal DIC after a reduction in tumor size. However, even in rats bearing AH109A tumor, we did not notice DIC after the efficacy of the drug had been slight. DIC does not result from adverse reactions of FCC itself. Onset of DIC correlated well with changes of blood coagulability. There were no relations between DIC following chemotherapy and coagulation activities in cells as well as tissues of two tumor strains.
| Original language | English |
|---|---|
| Pages (from-to) | 101-111 |
| Number of pages | 11 |
| Journal | Kareiigaku Kenkyusho Zasshi |
| Volume | 45 |
| Issue number | 3-4 |
| Publication status | Published - 1994 |
Keywords
- chemotherapy
- coagulation factors
- disseminated intravascular coagulation
- histopathology
- tumor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)