Dissecting tumour heterogeneity in flies: Genetic basis of interclonal oncogenic cooperation

Shizue Ohsawa, Daisaku Takemoto, Tatsushi Igaki

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Cancers develop through sequential acquisition of oncogenic mutations, indicating a crucial role of genetic alterations in tumour progression. However, accumulating evidence suggests that cancers also progress towards malignancy through cell-cell interactions within heterogeneous tumour tissue. Recent studies have indicated that tumour heterogeneity not only contributes to drug resistance and tumour recurrence but also plays an active role in promoting tumour progression. Especially, genetic studies in Drosophila have discovered novel types of tumour progression through cell-cell interactions and have dissected the underlying mechanisms. This review focuses on describing recent findings obtained from Drosophila genetics that provide genetic basis of interclonal oncogenic cooperation in heterogeneous tumour tissue.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalJournal of biochemistry
Volume156
Issue number3
DOIs
Publication statusPublished - 2014 Sep
Externally publishedYes

Keywords

  • Cell-cell interaction
  • Drosophila
  • Oncogenic cooperation
  • Tumour heterogeneity
  • Tumourigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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