Dissecting the molecular pathways of primary aldosteronism

Yasuhiro Nakamura, Saulo J.A. Felizola, Fumitoshi Satoh, Sachiko Konosu-Fukaya, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have been caused by aldosterone-producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). The differential diagnosis of both subtypes of PA is important due to the different therapeutic modes but clinically it is sometimes difficult. It is also important to understand the morphological features of these two subtypes with special emphasis upon differences of the status for aldosterone biosynthesis. In the last decade, molecular mechanisms of PA including the aberrant expression of G-protein coupled receptors (GPCRs), key regulators of the intracellular calcium signaling pathway and somatic mutations of ion channels, have been revealed and our understanding of the molecular pathways involved in excessive aldosterone production has been markedly advanced. In addition, newly developed monoclonal antibodies specific to the isoform of adrenal steroidogenic enzymes have demonstrated the novel profiles of adrenal steroidogenesis in PA. These novel findings indicate that the molecular mechanisms on the onset and pathophysiology of PA are more complicated than previously considered and further clarification of clinical relevance of these findings is required at this juncture.

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalPathology international
Issue number10
Publication statusPublished - 2014 Oct 1


  • Ca signaling pathway
  • G-protein coupled receptor
  • Primary aldosteronism
  • Somatic mutation
  • Steroidogenic enzymes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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