Abstract
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.
Original language | English |
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Pages (from-to) | 3084-3087 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 70 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2006 |
Externally published | Yes |
Keywords
- Caenorhabditis elegans
- Gene-disruption
- Insulin-like gene
- Lifespan regulation
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry