Disposition and metabolism of NY-198 V. Metabolism of 14c-ny-198 in rats and dogs

Osamu Nagata, Takehisa Yamada, Toshiaki Yamaguchi, Hiromichi Hasegawa, Eiichi Okezaki, Tetsuya Terasaki, Akira Tsuji

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16 Citations (Scopus)

Abstract

We studied metabolism of 14C-NY-198 in rats and dogs following oral administration of the drug. The metabolites of NY-198 in rat urine were identified as follows: M-I, unchanged NY-198; M-II, glucuronic acid conjugate of NY-198; M-IV and M-V, compounds cleaved at the piperazine ring; M-III and M-VI, compounds further metabolized through oxidative dealkylation of M-IV and M-V. In serum and urine of rats and dogs, mainly M-I was found, and amounted to more than 80% of the metabolites in these samples. The major metabolite in rat bile was M-II, followed by M-I. These results indicate that metabolism of NY-198 hardly occurs and that most of the drug remains unchanged in rats and dogs.

Original languageEnglish
Pages (from-to)174-187
Number of pages14
JournalChemotherapy
Volume36
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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