Disposition and metabolism of NY-198 II. Hplc and bioassay studies of absorption and excretion in the dog

Eiichi Okezaki, Eiichi Makino, Kohichi Ohmichi, Osamu Nagata, Takehisa Yamada, Kazuyo Takahashi, Testuya Terasaki, Akira Tsuji

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We investigated serum levels and urinary excretion of NY-198 using HPLC and bioassay methods after oral administration to dogs at a dose of 20mg/kg. Average serum levels of NY-198 reached a peak concentration of 8.95 μg/ml at 1 h after oral dosing, and then declined with a half-life of 7.1 h. NY-198 was excreted rapidly in urine after oral dosing, and the peak concentration was obtained in 6-12 hurine. A high urinary concentration of more than 50 μg/ml was maintained up to 48 h. Urinary excretion was 40.3% at 24 h and 51.8% at 72 h. Concentrations of NY-198 in serum and urine were measured by both HPLC and bioassay, and good correlation between the two assays was obtained. These results suggest that active metabolites possesing antimicrobial activity are not present in serum or urine after oral administration of NY-198.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalChemotherapy
Volume36
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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