Discriminative network models of schizophrenia

Guillermo A. Cecchi, Irina Rish, Benjamin Thyreau, Bertrand Thirion, Marion Plaze, Marie Laure Paillere-Martinot, Catherine Martelli, Jean Luc Martinot, Jean Baptiste Poline

Research output: Chapter in Book/Report/Conference proceedingConference contribution

32 Citations (Scopus)

Abstract

Schizophrenia is a complex psychiatric disorder that has eluded a characterization in terms of local abnormalities of brain activity, and is hypothesized to affect the collective, "emergent" working of the brain. We propose a novel data-driven approach to capture emergent features using functional brain networks [4] extracted from fMRI data, and demonstrate its advantage over traditional region-of-interest (ROI) and local, task-specific linear activation analyzes. Our results suggest that schizophrenia is indeed associated with disruption of global brain properties related to its functioning as a network, which cannot be explained by alteration of local activation patterns. Moreover, further exploitation of interactions by sparse Markov Random Field classifiers shows clear gain over linear methods, such as Gaussian Naive Bayes and SVM, allowing to reach 86% accuracy (over 50% baseline - random guess), which is quite remarkable given that it is based on a single fMRI experiment using a simple auditory task.

Original languageEnglish
Title of host publicationAdvances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference
Pages252-260
Number of pages9
Publication statusPublished - 2009 Dec 1
Externally publishedYes
Event23rd Annual Conference on Neural Information Processing Systems, NIPS 2009 - Vancouver, BC, Canada
Duration: 2009 Dec 72009 Dec 10

Publication series

NameAdvances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference

Conference

Conference23rd Annual Conference on Neural Information Processing Systems, NIPS 2009
CountryCanada
CityVancouver, BC
Period09/12/709/12/10

ASJC Scopus subject areas

  • Information Systems

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  • Cite this

    Cecchi, G. A., Rish, I., Thyreau, B., Thirion, B., Plaze, M., Paillere-Martinot, M. L., Martelli, C., Martinot, J. L., & Poline, J. B. (2009). Discriminative network models of schizophrenia. In Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference (pp. 252-260). (Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference).