Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum

Kei Oyama, Yukina Tateyama, István Hernádi, Philippe N. Tobler, Toshio Iijima, Ken Ichiro Tsutsui

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.

Original languageEnglish
Pages (from-to)2600-2615
Number of pages16
JournalJournal of Neurophysiology
Volume114
Issue number5
DOIs
Publication statusPublished - 2015 Nov 6

Keywords

  • Head-fixed rats
  • Pavlovian conditioning
  • Single-unit recording

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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