@article{6cea71f83bb946b6bfe5ab5b681c0597,
title = "Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach",
abstract = "Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new cyclic depsipeptide composed of l-leucine, l-tryptophan, and a polyketide moiety. Interestingly, the 10-membered macrocycle structure generated equilibrium to an unprecedented cyclol structure. This study demonstrates the advantage of a synthetic biology method in achieving rational access to new natural products. ",
author = "Yuto Homma and Akihiro Sugawara and Yohei Morishita and Kento Tsukada and Taro Ozaki and Teigo Asai",
note = "Funding Information: We thank Professor Katsuya Gomi (Tohoku University) and Professor Katsuhiko Kitamoto (The University of Tokyo) for providing the expression vectors and the fungal strain. This work was supported by JSPS KAKENHI (grant no. 19H04642 to T. Asai from Japan Society for the Promotion of Science (JSPS)), AMED under grant no. JP21wm0325003, JST FOREST Program (grant no. JPMJFR205W, Japan), the Naito Foundation and the Uehara Memorial Foundation. Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",
year = "2022",
doi = "10.1021/acs.orglett.2c01172",
language = "English",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
}