Discoloration and its prevention by surface treatment in high-purity water systems

Osamu Suzuki, Douglas Newberg, Mikio Inoue

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The interior surfaces of distillation units in pharmaceutical water systems are continuously exposed to hot, highly purified water and steam. This article describes an investigation of how various surface pretreatments inhibit the rate of discoloration of the process contact surfaces of SUS316L stainless steel water distillation equipment. Historically, well-polished metal surfaces have been used in high-purity water systems. The results of this study suggest, however, that portions of these systems, particularly surfaces in contact with hot, high-purity water or steam, will exhibit less discoloration and surface build-up if those surfaces are pretreated with pickling and passivation but not buffing.

Original languageEnglish
Pages (from-to)66-82
Number of pages17
JournalPharmaceutical Technology
Volume22
Issue number4
Publication statusPublished - 1998 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Pharmaceutical Science

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