Direct polymerization patterning based on eb lithography for control of cell adhesive orientation

N. Idota, T. Tsukahara, A. Hibara, T. Okano, T. Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we demonstrated a novel simple preparation process of the patterned polymer-grafted glass surfaces using electron beam (EB) lithography system without any photo-masks. N-isopropylacrylamide (NIPAAm) was locally polymerized and directly grafted onto surfaces only by single step of EB lithography. On these surfaces, cells adhered and spread with an orientation in accordance with the stripe pattern direction. When temperature decreased to 25°C, the cultured cells were detached from the surfaces and shrunken along the stripe pattern direction.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages430-432
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • Cell patterning cell adhesive orientation
  • EB lithographic polymerization
  • Thermoresponsive surface

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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