Abstract
(Chemical Equation Presented) A chiral diaryl prolinol silyl ether organocatalyst with an acidis used for the direct catalytic asymmetric Mannich reaction of acetaldehyde and imines. N-Benzoyl-, N-tert-butoxycarbonyl-, and N-toluene-4-sulfonylimines can be employed to produce synthetically useful β-amino aldehydes in goodyield s andwith excellent enantioselectivity (see scheme). The reaction mechanism was investigated quantum-mechanically.
Original language | English |
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Pages (from-to) | 9053-9058 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 47 |
DOIs | |
Publication status | Published - 2008 Nov 10 |
Externally published | Yes |
Keywords
- Acetaldehyde
- Asymmetric catalysis
- Imines
- Mannich reactions
- Organocatalysis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)