Direct observation of a target cell of the leaf-closing factor by using novel fluorescence-labeled phyllanthurinolactone

Hirotaka Sato, Masayoshi Inada, Takanori Sugimoto, Nobuki Kato, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We report the synthesis of the fluorescence-labeled probe 2 based on phyllanthurinolactone 1, which is a leaf-closing substance of Phyllanthus urinaria L. Bioorganic studies using probe 2 showed leaf-closing activity at 1 × 10-5 M, which was one-hundredth of that of the natural product 1. The fluorescence study using 2 revealed that the target cell for 1 is a motor cell and suggested that some receptors for 1 exist on the plasma membrane of the motor cell as with leaf-opening substances.

Original languageEnglish
Pages (from-to)5537-5541
Number of pages5
JournalTetrahedron Letters
Volume46
Issue number33
DOIs
Publication statusPublished - 2005 Aug 15

Keywords

  • Fluorescence
  • Glycosidation
  • Leaf-closing substance
  • Mitsunobu reaction
  • Motor cell
  • Nyctinasty
  • Probe compound

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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