Abstract
(Chemical Equation Presented) A variety of 1,2-dihydroisoquinoline derivatives 3 have been prepared in good to high yields by the AgOTf-catalyzed reaction of ortho-alkynylaryl aldimines 1 with various pronucleophiles 2 (see scheme). Treatment of 1 with a stoichiometric amount of AgOTf followed by protonation with TfOH produced 4, which suggests the formation of an isoquinolinium intermediate in the present direct addition reaction. Tf=trifluoromethanesulfonyl.
Original language | English |
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Pages (from-to) | 5526-5528 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 44 |
Issue number | 34 |
DOIs | |
Publication status | Published - 2005 Sep 2 |
Keywords
- Imines
- Mannich reaction
- Nitrogen heterocycles
- Pronucleophiles
- Synthetic methods
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)