Direct introduction of detachable fluorescent tag into oligosaccharides

Naoki Yoshida, Tsukasa Fujieda, Atsushi Kobayashi, Masaki Ishihara, Masato Noguchi, Shin Ichiro Shoda

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A novel oligosaccharide-labeling method involving the use of a detachable fluorescent tag has been developed based on the direct introduction of 4-methyl-7-thioumbelliferyl (MUS) group to the anomeric center of unprotected sugars. The resulting MUS-labeled sugars showed high sensitivity for fluorescence detection and could be used for quantification of oligosaccharides mixture. The unprotected sugars could be successfully recovered by a selective oxidative cleavage of the thioglycosidic bond under mild reaction conditions.

Original languageEnglish
Pages (from-to)1038-1039
Number of pages2
JournalChemistry Letters
Volume42
Issue number9
DOIs
Publication statusPublished - 2013 Sep 16

ASJC Scopus subject areas

  • Chemistry(all)

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