Direct intestinal absorption of red fruit anthocyanins, cyanidin-3- glucoside and cyanidin-3,5-diglucoside, into rats and humans

Teruo Miyazawa, Kiyotaka Nakagawa, Miyuki Kudo, Kayo Muraishi, Keita Someya

Research output: Contribution to journalArticlepeer-review

335 Citations (Scopus)

Abstract

We determined red fruit anthocyanins, cyanidin-3-glucoside (Cy-g) and cyanidin-3,5-diglucoside (Cy-dg), incorporated into plasma and liver of rats and human plasma by UV-HPLC. Fifteen minutes after an oral supplementation of a mixture of 320 mg of Cy-g and 40 mg of Cy-dg/kg of body weight, rats showed an increase to a maximum of 1563 μg (3490 nmol) of Cy-g/L and 195 μg (320 nmol) of Cy-dg/L in plasma and 0.067 μg (0.15 nmol) of Cy-g/g and a trace of Cy-dg together with methylated metabolites such as peonidin-3-glucoside in liver. In human plasma, 30 min after intake (2.7 mg of Cy-g and 0.25 mg of Cy-dg/kg of body weight), an average of 11 μg (24 nmol) of Cy-g/L and a trace of Cy-dg were found. Cyanidin as aglycone of Cy-g and Cy-dg was not found in such plasma samples, neither were conjugated and methylated anthocyanins. The results indicated that anthocyanins are incorporated keeping structurally intact glycoside forms, from the digestive tract into the blood circulation system in mammals.

Original languageEnglish
Pages (from-to)1083-1091
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume47
Issue number3
DOIs
Publication statusPublished - 1999 Mar 1

Keywords

  • Absorption
  • Anthocyanins
  • Catechin
  • Cyanidin glucoside
  • Metabolism

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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