Abstract
PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.
Original language | English |
---|---|
Pages (from-to) | 8185-8187 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 47 |
DOIs | |
Publication status | Published - 2005 Nov 21 |
Keywords
- Aqueous conditions
- Catalyst reuse
- Direct asymmetric aldol reaction
- Peptide catalyst
- Solid support
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry