Direct asymmetric aldol reaction in aqueous media using polymer-supported peptide

Kengo Akagawa; Seiji Sakamoto; Kazuaki Kudo

doi:10.1016/j.tetlet.2005.09.113

Direct asymmetric aldol reaction in aqueous media using polymer-supported peptide

Kengo Akagawa, Seiji Sakamoto, Kazuaki Kudo

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Abstract

PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.

Original language	English
Pages (from-to)	8185-8187
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	47
DOIs	https://doi.org/10.1016/j.tetlet.2005.09.113
Publication status	Published - 2005 Nov 21

Keywords

Aqueous conditions
Catalyst reuse
Direct asymmetric aldol reaction
Peptide catalyst
Solid support

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2005.09.113

Cite this

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abstract = "PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.",

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author = "Kengo Akagawa and Seiji Sakamoto and Kazuaki Kudo",

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AU - Akagawa, Kengo

AU - Sakamoto, Seiji

AU - Kudo, Kazuaki

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N2 - PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.

AB - PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.

KW - Aqueous conditions

KW - Catalyst reuse

KW - Direct asymmetric aldol reaction

KW - Peptide catalyst

KW - Solid support

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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ER -

Direct asymmetric aldol reaction in aqueous media using polymer-supported peptide

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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