Direct asymmetric aldol reaction in aqueous media using polymer-supported peptide

Kengo Akagawa, Seiji Sakamoto, Kazuaki Kudo

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)

Abstract

PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity.

Original languageEnglish
Pages (from-to)8185-8187
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number47
DOIs
Publication statusPublished - 2005 Nov 21

Keywords

  • Aqueous conditions
  • Catalyst reuse
  • Direct asymmetric aldol reaction
  • Peptide catalyst
  • Solid support

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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