Direct association of adenosine deaminase with a T cell activation antigen, CD26

Junichi Kameoka, Toshiaki Tanaka, Yoshihisa Nojima, Stuart F. Schlossman, Chikao Morimoto

Research output: Contribution to journalArticlepeer-review

428 Citations (Scopus)

Abstract

CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalScience
Volume261
Issue number5120
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • General

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