Diphenylprolinol silyl ether catalysis in an asymmetric formal carbo [3 + 3] cycloaddition reaction via a domino michael/knoevenagel condensation

Yujiro Hayashi, Maya Toyoshima, Hiroaki Gotoh, Hayato Ishikawa

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

Diphenylprolinol silyl ether was found to catalyze the formal carbo [3 + 3] cycloaddition reaction through the domino reaction via the Michael reaction, followed by Knoevenagel condensation of the α, β-unsaturated aldehyde and dimethyl 3-oxopentanedioate, affording substituted cyclohexenone derivatives with excellent enantioselectivity.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalOrganic letters
Volume11
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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