Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes

Hiroaki Gotoh, Hayato Ishikawa, Yujiro Hayashi

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

(Chemical Equation Presented) A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.

Original languageEnglish
Pages (from-to)5307-5309
Number of pages3
JournalOrganic letters
Volume9
Issue number25
DOIs
Publication statusPublished - 2007 Dec 6
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes'. Together they form a unique fingerprint.

  • Cite this