(Chemical Equation Presented) A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry