Dimerization of GTR1 regulates their plasma membrane localization

Yasuhiro Ishimaru, Kento Washiyama, Takaya Oikawa, Shin Hamamoto, Nobuyuki Uozumi, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Members of the nitrate transporter 1/peptide transporter family (NPF) are multifunctional transporters of various compounds including plant hormones and play important roles in plant growth and responses to environmental stress. Recently, we found that Arabidopsis GTR1 (also known as NPF2.10) takes up gibberellic acid and jasmonoyl-L-isoleucine in addition to glucosinolates. For normal plant growth, GTR1 is regulated at the gene expression level; however, it is unclear whether post-translational regulation also occurs. Here, we found that dimerization of GTR1, possibly induced by dephosphorylation of the Thr residue located between the possible transmembrane regions, regulates its plasma membrane localization, leading to transport of glucosinolates and gibberellic acid in Xenopus oocytes. These findings suggest that dimerization of multifunctional transporters contributes to their activities at the plasma membrane.

Original languageEnglish
Article numbere1334749
JournalPlant Signaling and Behavior
Volume12
Issue number6
DOIs
Publication statusPublished - 2017 Jun 3

Keywords

  • Dimerization
  • gibberellic acid
  • glucosinolate
  • jasmonoyl-L-isoleucine
  • transporter

ASJC Scopus subject areas

  • Plant Science

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