Diffusion-weighted magnetic resonance imaging of acute focal cerebral ischemia: Comparison of signal intensity with changes in brain water and Na+,K+-ATPase activity

Jan Mintorovitch, G. Y. Yang, Hiroaki Shimizu, John Kucharczyk, Pak H. Chan, Philip R. Weinstein

Research output: Contribution to journalArticlepeer-review

199 Citations (Scopus)

Abstract

Diffusion-weighted magnetic resonance (MR) images from rats during acute cerebral ischemia induced by middle cerebral artery occlusion were analyzed for correspondence with changes in brain water, cation concentrations, and Na+,K+-ATPase activity measured in vitro after 30 or 60 min of ischemia. In the ischemic hemisphere, signal intensity was increased at 30 min (p < 0.05 vs contralateral hemisphere) and further increased at 60 min. Na+,K+- ATPase activity was 34% lower in ischemic cortex and 40% lower in ischemic basal ganglia after 30 min (p < 0.05), but water content and Na+ and K+ concentrations were not significantly different between hemispheres. After 60 min, water content and Na+ concentration were increased, and both Na+,K+- ATPase activity and K+ concentration were decreased in the ischemic hemisphere (p < 0.05). These findings are consistent with the hypothesis that the early onset of signal hyperintensity in diffusion-weighted MR images may reflect cellular edema associated with impaired membrane pump function. Early in vivo detection and localization of potentially reversible ischemic cerebral edema may have important research and clinical applications.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume14
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Brain edema
  • Cerebral ischemia
  • Diffusion-weighted magnetic resonance imaging
  • Na,K-ATPase activity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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