Diffusion-weighted magnetic resonance imaging in dura mater graft-associated Creutzfeldt-Jakob disease

Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Hiroyuki Murai, Yasushi Iwasaki, Tadanori Hamano, Mari Honma, Moeko Noguchi-Shinohara, Ichiro Nozaki, Yosikazu Nakamura, Tetsuyuki Kitamoto, Masafumi Harada, Hidehiro Mizusawa, Masahito Yamada

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To elucidate the extension patterns of the hyperintense areas on diffusion-weighted magnetic resonance imaging (DW-MRI) in patients with dura mater graft-associated Creutzfeldt-Jakob disease (dCJD). Methods: We collected the DW-MRI of dCJD cases identified by the CJD Surveillance Committee in Japan, between April 1999 and February 2018. The dCJD cases were classified into non-plaque and plaque-types. The relationship among the abnormal signals, the pathological classification, and the sites of grafting were analyzed. Results: We collected DW-MRI of 11 patients with dCJD, all of whom were methionine homozygous at codon 129 of the prion protein gene. The age at onset was 41 (26–76) [median (range)] years, the age at dural grafting was 19 (10–53) years, and the incubation period was 22 (16–29) years. Eight dCJD cases were classified as non-plaque-type and three cases were plaque-type. Five of the non-plaque-type cases and all the plaque-type cases were pathologically confirmed. Brain DW-MRI was performed 3 (1−22) months after the onset. Most of the non-plaque-type cases showed brighter hyperintensity in the cerebral cortex and basal ganglia on the side of dural grafting. Subsequent DW-MRI showed widespread hyperintense lesions in the brain. Regarding the plaque-type cases, initial scans showed hyperintensity in the basal ganglia and the thalamus in one patient. Another patient's lesion was confined to the basal ganglia. The third patient showed no abnormalities seven months post-onset; however, serial images showed a hyperintensity confined to the thalamus. Conclusions: Non-plaque and plaque-types demonstrated different patterns of propagation of distinct prion strains.

Original languageEnglish
Article number117094
JournalJournal of the neurological sciences
Volume418
DOIs
Publication statusPublished - 2020 Nov 15
Externally publishedYes

Keywords

  • Diffusion-weighted magnetic resonance imaging
  • Dura mater graft-associated Creutzfeldt-Jakob disease
  • Non-plaque-type
  • Plaque-type
  • Thalamus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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