Diffusion tensor imaging fiber tractography for evaluating diffuse axonal injury

Ken Sugiyama, Takeo Kondo, Shuichi Higano, Minoru Endo, Hiroshi Watanabe, Keiichiro Shindo, Shin Ichi Izumi

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Patients with Diffuse axonal injury (DAI) frequently exhibit cognitive disorders chronically. Radiologic recognition of DAI can help understand the clinical syndrome and to make treatment decisions. However, CT and conventional MRI are often normal or demonstrate lesions that are poorly related to the cognitive disorders. Recently, diffusion tensor imaging (DTI) fiber tractography has been shown to be useful in detecting various types of white matter damage. The aim of this study was to evaluate the feasibility of using DTI fiber tractography to detect lesions in DAI patients, and to correlate the DAI lesions with the cognitive disorders. We investigated two patients with chronic DAI. Both had impaired intelligence, as well as attention and memory disorders that restricted their activities of daily living. In both patients, DTI fiber tractography revealed interruption of the white matter fibers in the corpus collosum and the fornix, while no lesions were found on conventional MRI. The interruption of the fornix which involves the circuit of Papez potentially correlates with the memory disorder. Therefore, DTI fiber tractography may be a useful technique for the evaluation of DAI patients with cognitive disorders.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalBrain Injury
Issue number4
Publication statusPublished - 2007


  • Circuit of Papez
  • Cognitive disorder
  • Corpus callosum
  • Diffuse axonal injury
  • Diffusion tensor imaging fiber tractography
  • Fornix

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology


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