Diffusion images on brain MRI in Creutzfeldt-Jakob disease

Utako Nagaoka, Keiji Kurita, Takaaki Hosoya, Tetsuyuki Kitamoto, Takeo Kato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We report a 72-year-old man with Creutzfeldt-Jakob disease. He showed a progressive dementia, myoclonus, and other neurological symptoms. DNA analysis showed a normal variation of prion gene (codon 129, Met/Met; codon 219, Glu/Glu). He had periodic synchronous discharge on electroencephalogram and brain atrophy on CT scan and MRI. Diffusion images on his brain MRI revealed a marked increase in signal intensity in the caudate nuclei, putamen, and cerebral cortices. These changes may represent spongy changes of the brain and seem to be a feature of brain MRI in Creutzfeldt-Jakob disease.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalClinical Neurology
Issue number4
Publication statusPublished - 1999 Apr


  • Creutzfeldt-Jakob disease
  • Diffusion image
  • MRI
  • Spongy change

ASJC Scopus subject areas

  • Clinical Neurology


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