Abstract
We report a 72-year-old man with Creutzfeldt-Jakob disease. He showed a progressive dementia, myoclonus, and other neurological symptoms. DNA analysis showed a normal variation of prion gene (codon 129, Met/Met; codon 219, Glu/Glu). He had periodic synchronous discharge on electroencephalogram and brain atrophy on CT scan and MRI. Diffusion images on his brain MRI revealed a marked increase in signal intensity in the caudate nuclei, putamen, and cerebral cortices. These changes may represent spongy changes of the brain and seem to be a feature of brain MRI in Creutzfeldt-Jakob disease.
| Original language | English |
|---|---|
| Pages (from-to) | 468-470 |
| Number of pages | 3 |
| Journal | Clinical Neurology |
| Volume | 39 |
| Issue number | 4 |
| Publication status | Published - 1999 Apr |
Keywords
- Creutzfeldt-Jakob disease
- Diffusion image
- MRI
- Spongy change
ASJC Scopus subject areas
- Clinical Neurology