Diffuse Lewy body disease searched out from 114 patients with parkinsonism

Kazutaka Jin, N. Sato, K. Hisanaga, H. Suzuki, H. Mochizuki

Research output: Contribution to journalArticle

Abstract

From 114 patients who had been previously diagnosed as Parkinson's disease, we diagnosed six cases as clinically definite 'diffuse Lewy body disease (DLBD)' according to McKeith's criteria with more strict modifications. Besides a central feature, dementia, and core features including parkinsonism, fluctuating cognition, and recurrent visual hallucinations, the patients presented some of supportive features, that is, repeated falls (4 cases), syncope (5 cases), and transient loss of consciousness (all cases). Autopsy, which was performed in 2 of the cases, revealed Lewy bodies in various nervous tissues including autonomic nervous systems in both cases. 7 cases of probable DLBD and 8 cases of possible DLBD, which lacked fluctuating cognition and/or visual hallucinations, demonstrated neither of repeated falls, syncope, nor transient loss of consciousness. Episodes of these supportive features, which seem to be associated with autonomic dysfunctions and/or fluctuating cognition, should be important in the differential diagnosis of DLBD.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalClinical Neurology
Volume40
Issue number4
Publication statusPublished - 2000 Sep 26
Externally publishedYes

Keywords

  • Autonomic dysfunction
  • Dementia
  • Lewy bodies
  • Parkinsonism

ASJC Scopus subject areas

  • Clinical Neurology

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    Jin, K., Sato, N., Hisanaga, K., Suzuki, H., & Mochizuki, H. (2000). Diffuse Lewy body disease searched out from 114 patients with parkinsonism. Clinical Neurology, 40(4), 329-333.