TY - GEN
T1 - Differentiation of vein and lymphatic vessel by photoacoustic imaging system with parabolic array transducer and tunable laser
AU - Tabata, Takuya
AU - Nagaoka, Ryo
AU - Umemura, Shinichiro
AU - Saijo, Yoshifumi
AU - Yoshizawa, Shin
N1 - Funding Information:
This work was also supported by Grants-in-Aid for Scientific Research (Scientific Research (B) 26282142, Challenging Exploratory Research 25560235) from the Japan Society for the Promotion of Science
Funding Information:
ACKNOWLEDGMENT This work was funded by ImPACT (Impulsing Paradigm Change through Disruptive Technologies) Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan). This work was also supported by Grants-in-Aid for Scientific Research (Scientific Research (B)
Publisher Copyright:
© 2017 IEEE.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - Recently, much attention is being paid to lymphatic circulation because intralymphatic immunotherapy and chemotherapy achieved significant clinical benefits. However, conventional ultrasound or photoacoustic (PA) imaging is hard to visualize lymphatic vessels. In the present study, real-time three-dimensional PA imaging system consisted of 256-ch parabolic array transducer with the central frequency of 10 MHz and tunable laser with the wavelength of 400-2100 nm was developed. Photoacoustic contrast agents such indocyanine green (ICG) or gold nanorods (AuNRs) were administrated to the lymphatic vessels of the ICR mouse. The vein was visualized at the wavelength of 490-600 nm without contrast agents. The lymphatic vessel was visualized at 670-770 nm with ICG and at 790-890 nm with AuNRs. The system is clinically applicable for detection of small lymphatic vessels to confirm successful drug delivery during intralymphatic chemotherapy.
AB - Recently, much attention is being paid to lymphatic circulation because intralymphatic immunotherapy and chemotherapy achieved significant clinical benefits. However, conventional ultrasound or photoacoustic (PA) imaging is hard to visualize lymphatic vessels. In the present study, real-time three-dimensional PA imaging system consisted of 256-ch parabolic array transducer with the central frequency of 10 MHz and tunable laser with the wavelength of 400-2100 nm was developed. Photoacoustic contrast agents such indocyanine green (ICG) or gold nanorods (AuNRs) were administrated to the lymphatic vessels of the ICR mouse. The vein was visualized at the wavelength of 490-600 nm without contrast agents. The lymphatic vessel was visualized at 670-770 nm with ICG and at 790-890 nm with AuNRs. The system is clinically applicable for detection of small lymphatic vessels to confirm successful drug delivery during intralymphatic chemotherapy.
KW - Gold nanorod
KW - Lymphatic vessel
KW - Photoacoustic imaging
KW - Tunable laser
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U2 - 10.1109/ULTSYM.2017.8091574
DO - 10.1109/ULTSYM.2017.8091574
M3 - Conference contribution
AN - SCOPUS:85039442819
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017
Y2 - 6 September 2017 through 9 September 2017
ER -