Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231

Katharina Buerger, Raymond Zinkowski, Stefan J. Teipel, Hiroyuki Arai, John DeBernardis, Daniel Kerkman, Cheryl McCulloch, Frank Padberg, Frank Faltraco, Alexander Goernitz, Tero Tapiola, Stanley I. Rapoport, Tuula Pirttilä, Hans Jürgen Möller, Harald Hampel

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

Objective: Differentiation of geriatric major depression from Alzheimer's disease is hampered by overlapping symptoms. Increased CSF concentrations of tau protein phosphorylated at threonine 231 (p-tau231) have been suggested as a biomarker for Alzheimer's disease. The authors asked whether p-tau231 levels improve the differential diagnosis between geriatric major depression and Alzheimer's disease. Method: Included were 34 depression subjects, 64 with probable Alzheimer's disease, 17 with possible Alzheimer's disease, and 21 healthy comparison subjects. P-tau231 concentrations were measured with an enzyme-linked immunosorbent assay. Results: P-tau 231 levels were significantly higher in Alzheimer's disease than in geriatric major depression patients and healthy comparison subjects. For differentiation of probable Alzheimer's disease from major depression, p-tau231 correctly allocated 87% of subjects. When possible mild Alzheimer's disease was compared to major depression, p-tau231 correctly allocated 78% of subjects. Conclusions: CSF p-tau231 should be evaluated as a potential biological marker for differentiation of geriatric depression from Alzheimer's disease.

Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalAmerican Journal of Psychiatry
Volume160
Issue number2
DOIs
Publication statusPublished - 2003 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231'. Together they form a unique fingerprint.

Cite this