Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes

Y. Yamaguchi-Iwai, M. Satake, Y. Murakami, M. Sakai, M. Muramatsu, Y. Ito

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.

Original languageEnglish
Pages (from-to)8670-8674
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number21
DOIs
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • endoderm
  • gene regulation
  • retinoic acid
  • transcription factor AP1

ASJC Scopus subject areas

  • General

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